Clinical Trials Bring the Most Advanced Therapies to Southern Indiana

November 10, 2008

Clinical trials are research studies that help increase our understanding of diseases and treatments, and can provide patients with the opportunity to receive leadingedge therapies before they become available on a widespread basis. Floyd Memorial and the Joslin Diabetes Center Affiliate have very active clinical trial programs, which often mean our patients don’t have to travel across the country to receive some of the world’s most advanced treatments.

Two Inpatient Trials at Floyd Memorial Several clinical trials are now being conducted among inpatients. Ryan Pickhardt, CRC, clinical research coordinator described two of them. “The first,” said Pickhardt, “involves patients who have healthcare-acquired pneumonia with MRSA (Methicillin- Resistant Staphylococcus Aureus). For decades, Vancomycin has been the standard of treatment. This study is designed to determine whether a new drug called Zyvox is more effective against this pneumonia. We are participating with 160 sites around the world.” The second study involves patients with a severe multi-organ dysfunction called sepsis. According to Pickhardt, “It is designed to determine the effectiveness of a drug called Talactoferrin, a form of protein found in breast milk, in keeping infection from spreading from the digestive system to the bloodstream. Findings could benefit some of the most severely ill patients.”

Three Studies Now Enrolling at the Joslin Diabetes Center Affiliate

Debra Walker, RN, CCRP, is the clinical research coordinator at Joslin. As she explained, “We are currently studying the effectiveness of a new drug that’s given by injection once a week. It was developed to help lower blood sugar and aid in weight loss. This is a 52-week study involving several countries.”

  • Requirements for participation: Type 2 diabetes that is not well controlled by diet, exercise and oral medication; hemoglobin A1C between 7 and 10 “We are also working with the University of Louisville in a study on the way high blood sugars alter cells that regulate the immune system,” said Walker. “This study involves one or two visits to the lab.
  • Requirements for participation: Type 1 or 2 diabetes; A1C greater than 8; not currently a smoker Another study with U of L involves a written questionnaire that will take 20 or 30 minutes to complete. “It is designed to help researchers better understand the effect of diabetes-related stress on glucose control,” explained Walker.
  • Requirements for participation: Type 2 diabetes, willingness to share attitudes and emotions • Upcoming studies in 2009 include: – Comparing two treatments in patients with type 2 diabetes – Obesity study – Insulin delivery device study

To find out if you are eligible to participate in any of these studies, please call (812) 981-6684.